Rough Running Engine and Possible Check Engine Light on Ford E-350

The Check Engine Light may illuminate, the engine may run rough and have misfires on acceleration. Commonly the ignition coils and/or the ignition coil boots are the cause of this problem. The rubber boot that insulates the coil to the spark plug can dry and crack allowing arcing. Inspect the coils and boots, and replace them as needed. Our technicians also recommend replacing the coil boots any time the spark plugs are replaced.

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Average mileage: 163,428 (40,000–335,000)
Engines affected: 4.9L 6 Cylinder, 5.4L V8, 5.8L V8, 6.8L V10, 7.5L V8
17 model years affected: 1994, 1997, 1998, 1999, more2000, 2001, 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012
45 people reported this problem
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problem details
1998 Ford E-350 - 6.8L V10 144,000 mi,
After spark plugs were replaced, check engine light came on. Hesitation upon acceleration, and misfires and popping.
1999 Ford E-350 - 5.4L V8 200,000 mi,
bucking while going up hill with a trailer and theres no check engine light
1994 Ford E-350 - 7.5L V8 128,000 mi,
Will run ruff untill warmed up misseswhen ideling missed when running at a study speed does not miss on exceluation. It FL
2007 Ford E-350 - 5.4L V8 40,000 mi,
Rough running out of the blue, check engine light, valve dropped and fried, spark plug melted, new engine. I will never buy Ford again.
miss fire, new plugs and two new coils
1997 Ford E-350 - 6.8L V10 335,000 mi,
Runs rough going up hills. Its my first engine problem. I got me a good V10.
2007 Ford E-350 - 4.9L 6 Cylinder 150,000 mi,
Flashing check orange check engine problem. Uneven engine run. Loss of power during acceleration.
2002 Ford E-350 - 5.4L V8 150,000 mi,
I have this problem