The camshaft adjuster solenoid (which is related to the variable valve timing system) may fail or timing chain/balance shaft components may wear, resulting in illumination of the Check Engine Light and various drivability issues. Mercedes-Benz has released a service bulletin outlining specific repair instructions depending on fault codes stored.
Car Problem Reports
Mercedes-Benz E350 4MATIC Camshaft Adjuster Solenoid Failure
Mercedes-Benz E350 4MATIC Problem
Average Mileage: 53,192 mi (22,000 mi - 80,439 mi)
Visitor, 2008 Mercedes-Benz E350 4MATIC, 33,521 mi
Replaced - under warranty
Visitor, 2009 Mercedes-Benz E350 4MATIC, 70,000 mi
Check engine light caused by Camshaft Adjuster Solenoid Failure
Visitor, 2010 Mercedes-Benz E350 4MATIC, 22,000 mi
When I turned on the car the windshield wipers went on and wouldn't go off--even in the off position. I turned the car off and restarted it--then I had no windshield wipers and no turn signals. When I arrived home I turned the car off and removed the key--it kept "dinging" and telling me to turn off lights and remove key--they were both done. Meanwhile the check engine light was on. Since it was a Saturday and I knew the battery would be dead by Monday morning when the service department opened I had the car towed in to the dealership by Mercedes Roadside Service. The tow truck driver was able to "click" through the smart key and turn off the lights. Long story short, when the dealership looked at the car on Monday morning it was the solenoid something or other....it was replaced for free as my car is still under warranty.
Check engine light came on. I checked the gas tank cap and restarted a neumer of times -- still on
Went to the dealer - diagnosed as fault 0060 & 0064 Comgruant with LI 05.20-P-051268 and replaced the right and left bank camshaft solinoid (Y49/7, Y49/6) and Cam Magnets