Irregular and premature tire wear can be caused by the front thrust link bushings cracking and causing excessive movement in the suspension. The thrust link bushings are fluid-filled (to help reduce vibration), so if they crack, they will leak oil.Google+
Car Problem Reports
Mercedes-Benz E320 4MATIC Tire Wear Caused By Worn Front Thrust Link Bushings
Mercedes-Benz E320 4MATIC Problem
Average Mileage: 106,328 mi (88,000 mi - 115,493 mi)
Have gone threw two sets of 60k tires and the original set. Had car checked out and was told that all of the suspension system and bushings were good.
Visitor, 2004 Mercedes-Benz E320 4MATIC, 115,493 mi
Have gone through 2 sets of tires in the last 4 years and these don't include the original ones. The tires were rated at 50k, but didn't hardly get 20k out of them. Service checked all bushings and suspension and said everything looked good.