The early versions of the central gateway module (which allows different systems to communicate with each other) have software problems.Google+
Car Problem Reports
Mercedes-Benz E320 CDI Early Versions of Central Gateway Module Have Software Problems
Mercedes-Benz E320 CDI Problem
Visitor, 2005 Mercedes-Benz E320 CDI, 90,000 mi
While driving on I-95 suddenly my dashboard warning signals started flashing one after another. Car then lost power with dead gas pedal. Was able to coast onto emergency lane to await tow. Car still in shop but have been told that central gateway computer was 'down'.