The early versions of the central gateway module (which allows different systems to communicate with each other) have software problems.
Car Problem Reports
Mercedes-Benz E500 Early Versions of Central Gateway Module Have Software Problems
Mercedes-Benz E500 Problem
Average Mileage: 87,750 mi (80,000 mi - 95,500 mi)
Visitor, 2004 Mercedes-Benz E500, 80,000 mi
4 error messages appeared to include SOS, SRS, check engine and low oil. Popping noises in the audio system and a loud roaring noise from the engine also occurred.
Visitor, 2003 Mercedes-Benz E500, 95,500 mi
While traveling in Florida from Texas the Central Gateway failed. This failure caused the car to become inoperable!!!!!! Mercedes sold us a defective vehicle!!!!