CD changers, command units, voice control units, PSE units, and Tele Aid units are prone to failure, especially in early models.Google+
Car Problem Reports
Mercedes-Benz S500 CD Changers and Command/Voice Control/PSE/Tele Aid Units May Fail
Mercedes-Benz S500 Problem
Average Mileage: 102,849 mi (45,000 mi - 160,000 mi)
Visitor, 2001 Mercedes-Benz S500, 93,000 mi
Command screen has vertical line running through display
CD changer shows empty magazine message.
Visitor, 2004 Mercedes-Benz S500, 108,000 mi
Bought the car a year ago used and the CD changer won't eject and the console won't acknowledge the changer exists. No voice control anywhere to speak of.
Visitor, 2000 Mercedes-Benz S500, 136,698 mi
CD changer in Control panel just shuts down then the whole control panel needs to be stopped and restarted for it to work again. I haven't had it diagnose because I am broke from fixing airmatic suspension issues with just one strut.
Visitor, 2003 Mercedes-Benz S500, 134,000 mi
no sound from command center and doesnt recognize cd changer
Visitor, 2001 Mercedes-Benz S500, 108,000 mi
The cd changer always says "empty magazine",TELE-AID warning
Visitor, 2005 Mercedes-Benz S500, 80,345 mi
It stuck when i put it in
Cd player reads empty.Wont play.
Visitor, 2006 Mercedes-Benz S500, 66,000 mi
Command center panel not power on.
voice command never worked.Tele Aid unit works but since change from anaylog to digital I guess that is normal.
Visitor, 2006 Mercedes-Benz S500, 45,000 mi
command center quit working, shop says put in new center, not done yet