Does a tune-up require timing adjustment after replacing spark plugs?

We don't use the phrase tune-up anymore. When it is finally time to do the plugs, (approx. 90K) if serviceable you should plan on doing the plug boots what go between the coils and the plugs. Things like cleaning the throttle body, throttle plate can be done at the same time, or on a totally individual basis. the same goes for air filters, fuel filters etc. You asked a question however about is it really necessary to replace the wires when changing the plugs. While not on your car since you don't have "plug wires", (you should change the coil boots if possible) on other cars that do it really is necessary for several reasons. Everything from the insulation drying out over time and not being strong enough to tolerate being removed without stressing, to scratching the new spark plug all can encourage carbon tracking to begin and that makes for a potential path for the spark to leak out and not be forced to fire the gap of the plug in the cylinder which results in a misfire. Misfires kill catalytic convertors, so plugs, and wires where applicable should always be replaced together. IMO.

How many miles on the car? 2011 right?

no timing adjustment should be necessary but yes it is a good idea to change wires at time of spark plug replacement.