An intermittent no start condition may be caused by a failed "Push Start" switch. Replacing the failed switch should correct this concern.Google+
Car Problem Reports
Lexus LS460 Intermittent No Start Due to Failed "Push Start" Switch
Lexus LS460 Problem
Average Mileage: 43,238 mi (22,000 mi - 62,000 mi)
Visitor, 2007 Lexus LS460, 51,500 mi
Push the button. Tries to start. seems to just die. Push again and it starts
Visitor, 2008 Lexus LS460, 62,000 mi
intermittent clicking and no start. Will start with a couple of tries
Visitor, 2008 Lexus LS460, 52,110 mi
I will push the brake, green light comes on, I will push the starter button and nothing, sometimes it doesn't start until the 3rd or 4th time. I have replaced the battery in both the car and the FOB, still not fixed. In shop now for a diagnostic.
Visitor, 2008 Lexus LS460
I had the same problem I was pushing the start button too hard I was starting it and killing it at the same time. Now all I do is barely push the start button. Try it. It worked for me.
Visitor, 2011 Lexus LS460, 33,822 mi
It just happened today. . . I have not had it diagnosed or fixed yet.
Visitor, 2007 Lexus LS460, 38,000 mi
About 1 in 20 times the car does not start on the first try.
Visitor, 2011 Lexus LS460, 22,000 mi
Having ignition/satrting problems. Has not been corrected.