Changed a fuel injector, now cranks a lot before starting.

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Vehicle used to start immediately. When warm but off for 20 mins or so, would start right up but idle rough as if on 5 cylinders, this would go away after a few minutes. Then finally CEL w/code P0303. I replaced #3 F.I., now initial problem is gone, however now has new symptoms: 1) Excessive cranking before it finally starts 2) Runs rough upon start-up for about 30 seconds (hot or cold), but runs fine after that. 3) Recent CEL w/codes P0303 & P0328 (new entries - I had reset the computed after the FI change). Question: When changing a fuel injector, should the fuel lines be bled somehow? If not, any ideas for me? Thanks!