The 4.7 engine has 2 codes PO301 and PO351. I changed all 8 plugs and the coil on cylinder 1 but that did nothing. It still runs rough and spits out the same 2 codes. WHY??

What is your question?

It runs like it is only hitting on 7 out of 8 spark plugs and sometimes shuts off when I start out. I have to run it with 1 foot on the brake and the other on the gas pedal to keep it going. I no sooner clear the codes and they come right back on even after changing the plugs and the coil on cylinder 1.