Ford E-350 Problems

Rough Running Engine and Possible Check Engine Light on Ford E-350

Problem Description and Possible Solution

The Check Engine Light may illuminate, the engine may run rough and have misfires on acceleration. Commonly the ignition coils and/or the ignition coil boots are the cause of this problem. The rubber boot that insulates the coil to the spark plug can dry and crack allowing arcing. Inspect the coils and boots, and replace them as needed. Our technicians also recommend replacing the coil boots any time the spark plugs are replaced.

(55 people reported this problem)

Ford E-350 Vehicles With This Problem

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Average mileage: 165,163 (40,000–335,000)
Engines affected: 4.9L 6 Cylinder, 5.4L V8, 5.8L V8, 6.8L V10, 7.5L V8
18 model years affected: 1994, 1995, 1997, 1998, more1999, 2000, 2001, 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012
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Viewing 1-12 of 12 comments
After spark plugs were replaced, check engine light came on. Hesitation upon acceleration, and misfires and popping.
Will run ruff untill warmed up misseswhen ideling missed when running at a study speed does not miss on exceluation. It FL
Runs rough going up hills. Its my first engine problem. I got me a good V10.
Rough running out of the blue, check engine light, valve dropped and fried, spark plug melted, new engine. I will never buy Ford again.
Flashing check orange check engine problem. Uneven engine run. Loss of power during acceleration.
I recently bought my E350 7.5 liter..and it spits black smoke out and idles roughly!Has a hard time getting started! I changed the fuel pressure regulator....still the same .....I'm going to change the ignition coil and the oil next along with the air filter!! Anything else I should check? Vacuum lines seem ok......
Miss firing while acceleratining and it takes a long time for speed to increase while going up the hill and when I release the gas then the air condition turns back on
Loss of power. smooth acceleration and choking. Are changes gas an added cause?
When should a diagnostic test be performed?