Rough Running Engine and Possible Check Engine Light on Ford E-150

The Check Engine Light may illuminate, the engine may run rough and have misfires on acceleration. Commonly the ignition coils and/or the ignition coil boots are the cause of this problem. The rubber boot that insulates the coil to the spark plug can dry and crack allowing arcing. Inspect the coils and boots, and replace them as needed. Our technicians also recommend replacing the coil boots any time the spark plugs are replaced.

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Average mileage: 136,609 (41,000–245,000)
Engines affected: 4.2L V6, 4.6L V8, 5.4L V8
14 model years affected: 1997, 1998, 1999, 2000, more2001, 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010
68 people reported this problem
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Viewing 1 - 19 of 19 problem details
2000 Ford E-150 - 5.4L V8 150,145 mi,
driving down the road the check engine light starts flashing and the front end starts shaking then it stops for a while and does it again real sulgish during this time
2003 Ford E-150 - 4.6L V8 65,000 mi,
the motor started missing lightly at first and real bad later. after scanning it was found to have a bad coil #7 cylinder i believe. I replaced the coil and problem was solved,but only for about three weeks, and it started all over again. I replaced the coil again and problem solved for about three weeks again. This missing is usually bad with acceleration. can the coil boot be the problem,and if so why does it not miss for about three weeks.
2002 Ford E-150 - 5.4L V8 145,000 mi,
Engine stumbles going uphill at times, hesitates at other times on flat road. Hesitates on acceleration from stop. Got "#5 cylinder misfiring" diagnostic message. Ran great for 2 days, then same problems.
2002 Ford E-150 - 5.4L V8 150,000 mi,
engine runs rough and misfires... changed plugs, fuel pump, cleaned and checked egr. changed o2 sensors, problem still persists
2000 Ford E-150 - 4.2L V6 214,000 mi,
Rough running engine and pinging as if the timing has changed. The check engine light blinks.
2001 Ford E-150 - 4.2L V6 120,000 mi,
It was shaking and rough while driving and engine light came on flashing then went away
1997 Ford E-150 - 4.6L V8 170,000 mi,
Truck was miss firing, running like crap, cel was flashing when I accelerated. I cleaned my mass air flow system out, cleaned the throttle body out and im about to check the code tomorrow.
2000 Ford E-150 - 4.6L V8 82,000 mi,
replaced only select coils. Vehicle is doing better but still running rough when it goes uphill or putting a load on it.
2005 Ford E-150 - 4.6L V8 64,000 mi,
Had same problems over about a 6 week time frame. After replacing coil wires, boots, a fuel pump, and spark plugs the dealer finally sent data to Ford. Within an hour Ford diagnosed a wiring harness problem. Wiring harness was against manifold causing intermittent shorts. Spent over $2,000 for a $100 fix. But vehicle runs fine now
2003 Ford E-150 - 4.2L V6 94,000 mi,
low conpression on #2 cylinder running lean new plugs, wires, coil, checked out by garage.
2001 Ford E-150 - 4.2L V6 205,465 mi,
Engine was "surging" under load....uphill or exceleration. CEL came on....went to O'riely's....code showed to be "detonation" ...bought and Replaced plugs and wires...truck ran good for about 2-3weeks.....surge is back...now looking to change coil packs....any idea as how to fix this problem once and for all.
1997 Ford E-150 - 4.6L V8 200,000 mi,
Run rough until get to2000 rmp
heater core line n front of motor metal line is cracked
i have the same issue i have replaced the fuel pump and it seemed to run good and now its back to running rough again
2006 Ford E-150 - 4.6L V8 81,000 mi,
Same problem.
2003 Ford E-150 - 5.4L V8 140,000 mi,
Ignition coils
2005 Ford E-150 - 5.4L V8 113,000 mi,
Running rough smelling gas at idle and engine light on.
2000 Ford E-150 - 5.4L V8 150,000 mi,
hesitates occasionally on right turns only. no idea why.
1998 Ford E-150 - 4.2L V6 156,000 mi,
engine idle was rough, and cel was flashing