Is it ok to have two different sized tires on the rear of the vehicle,225/65R16 and the other side is 22570/R16..

Hi this is Dusty, I'm one of the auto experts on RepairPal's Car Genius team. Differentials are constructed in a way that intentionally allows each wheel to rotate at different speeds, so damage is unlikely. You're more likely to experience erroneous ABS operation, negative impact to the vehicle's handling characteristics, and discrepancies in speedometer readings. Anytime a vehicle is equipped with ABS, the tire sizes need to be the same so that the system can perform properly. Vehicles with staggered wheel sets or atypical wheel and tire combinations from the factory have had those variables taken into consideration during the engineering process. All these items carry an inherent safety concern, I would strongly recommend that the tires be matched accordingly to the factory equipment (the original tire size and configuration is on a placard inside the driver's door opening) as soon as possible. If you have any questions, give us a call at (877) 913-1554