What could cause the van to not go when put into drive

What is your question?

Was driving home when it acted like I ran out of gas but didn't limped it home at 10 miles per hour got home shut it off and restarted it and it had a loud wine noise coming from underneath now it will not go any where when it's put into drive or reverse but still makes noise only when you smash the gas pettel no matter what gear it's in