Why did it shake and make a clunking sound and then stopped pulling e320 4matic

What is your question?

I was driving down the road after just tradeing for the 02 e320 awd he had a blow out on the way to trade put the spare on wich is a 215/65/16 and the rest are 215/55/16 was running great then i hit the gas to take off and my tractimg kept kicking in finally got it going hwy speed and about 2 hours into the drive home it start shaking then made a clunk noise and stoped pulling when you got to put it in park it's like it didn't have a drive shaft connected because it grinds into park but you can feel it go in but it will still roll around I was wondering if this could be t-case drive shaft trans or what ?