How do I replace the water line? Any advice?

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The line is a u-shaped piece that carries coolant from the driver's side of the engine block to the coolant reservoir on the passenger side of the engine compartment by traveling behind the engine block. It also feeds the water valve, which connects to the inflow and outflow lines of the passenger compartment's heater core. The piece's metal section hangs on hooks located below the exhaust manifold on block's passenger side. It's a convoluted routing that seems to render replacement impossible without dropping the transmission or perhaps pulling the gear shifter. Does anyone have experience with this repair?