What's with 2006 rx 330 sunroof leaks when closed

Check the front two corners. There're small drain lines that typically get plugged from leaves and other debris. Use a can of compressed air with a straw and gently blow through those drains. That should help drainage. Otherwise, it could be the seal itself which is costly to replace as it's part of the glass and required extensive knowledge and time to fix. Good luck! Mine is my 2006 es330 is starting to make noises when closing. I'm scared haha. It doesn't leak though so I guess that's good! Let us know if that corrects the leaking problem