Changing spark plugs/wires, tuneup on 2007 Honda accord v6. Must I change coils

What is the symptom you are experiencing? Do you have a record of diagnostic trouble codes that have been set? Has a diagnostic test procedure been run to see what the source of the problem is? You can always replace parts, but sometimes it might be a waste of money to replace something that works as designed still. There is no "must" to changing coils unless you can verify one or more has failed.