Cant find what causing my 2000 yukon to have random misfires

Hello, my first question - what quality parts have you used? Original GM parts? If not, try original GM parts first and recheck operation. Also, if the problem persists, consider performing a compression and leak down test of the engine - you may find some concerns there. Use this link to find a shop near you that can help: www.repairpal.com/repair-shops