In cases like these the most common problem is something electrical like a module or a fuel pump. Gets hot, heat soaks when you shut it off and wont work again until it cools down. Need to catch it in that act to diagnose properly.
RepairPal Certified shops can diagnose and repair your 2000 Ford F-250 Super Duty. They provide transparent pricing with a minimum 12-month or 12,000-mile warranty on repairs and services.
Thank you