2001 4 door Ford F150 cranks but won't start, what's the issue?

Hello, before you can jump to a guess of any fuel system component, you'll need to see if the engine is receiving fuel delivery. Just because you can hear a pump - if that's what you're hearing - doesn't mean it's working and delivering any or enough fuel. Once you know if the fuel is there or not, using a fuel pressure gauge to measure consistency and sufficient pressure, you can move further down the diagnostic path of fuel system issue or go to ignition system issues - such as coils, plugs or something in that area. Additionally, before anything - have you checked the fuel pump cut off (inertia) switch to see if it has been tripped? This is located behind the passenger floor kick panel. This could be the culprit. Use this link to find some shops near you that can help with your concern: www.repairpal.com/repair-shops