2004 Dodge Ram 1500: Does electronic throttle body need to be programmed after replacing?

You shouldn't need to with the Dodge Ram 1500,bbut you may have a throttle pedal sensor issue. Why did you replace it and what codes did you have?

Try this: Get in your truck, turn the key to ON position (do not start the engine!) and within 3 seconds push the accelerator pedal to the floor and let it back. Turn the key off, than start it and see if it's working good now.