Have a crew cab Colorado. Driver side window and door locks will not work.

Remove the 2 screws in the door handle. Disconnect the 3 wire connectors. Remove the assembly. After a couple of hours Reassemble the unit. This seems to reset the relays in the circuit board. Mine quit working after working on my truck with the battery disconnected. I did the above and it worked fine afterwards. If this doesn't resolve your problem, then you may purchase the three relays that are on the circuit board through Mouser Electronics and replace them. It's a $15.00 fix., with access to a soldering station.