lifters knocking

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NEW LIFTERS IN VEHICLE IF I PUT LUCAS OIL IN THE MOTOR SHOULD I USE SYNTHETIC SINCE IT IS 5W20 OIL AND WHAT WOULD MAKE THE LIFTERS PECK WHEN IT IS FIRST STARTED IF I HAVE CHANGED THE LIFTERS. THE VEHICLE HAS 104,000 MILES BUT GOOD OIL PRESSURE AND RUNS FINE THIS ONLY DOES IT FOR A FEW MINUTES THAN YOU CAN DRIVE A 100MILES AND NEVER MAKE A SOUND