The door for the vanity mirror (or the frame for the door) can break; due to a redesign, the mirror "cassette" will need replacement.
Car problem reports
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Most reported Mercedes-Benz S500 4MATIC problems
The center console armrest can break. Replacement is commonly the recommended repair.
The relay which turns the airmatic suspension pump on may fail causing the pump to run continuously. This can result in failure of the pump motor or a dead battery as the pump motor will continue to run after the car is turned off. Also, Worn airmatic pump mount bushings can causes noises in the front axle while driving on bumpy roads or a buzzing noise while the pump is running.
A door control module/actuator may fail. Our technicians recommend finding an expert to repair them. Taking the door trim panels off requires expert knowledge because they can break and the pieces are very expensive.
The engine may develop a stalling and/or no start condition due to a failed crankshaft position sensor.
Due to the size and material used on the brakes of these vehicles, the brakes may start to squeak around the 50 percent wear point. The brake rotor surfaces become uneven, causing a lip to form at the outer edge of the rotor. Because of this, the rotors are usually replaced when the pads are worn (pad life varies depending on driving style and terrain).
High mileage or older vehicles commonly develop leaks from the differential seals and/or cover. Our technicians recommend a complete reseal of the differential unit whenever these leaks are repaired.
An engine oil leak may develop from the oil level sensor. Replacement of the leaking sensor will commonly correct this concern.
The ESP and BAS warning lights may illuminate due to a failed brake light switch. Replacement of the failed switch should correct this concern.
An engine Oil leak may develop from the PCV vent housing on the valve cover and/or the inspection plate on the front of the engine.