Some Lexus ES350 owners report experiencing severe vibrations and shaking at speeds over 60 mph, which may be attributed to a defective axle assembly. These unusual vibrations, particularly during acceleration, can indicate a failing CV axle, resulting in a worsening shuddering sensation. Excessive vibrations may stem from a damaged axle shaft or CV joint, while issues with the inner joint of the axle could cause a shaking sensation, and loud popping or clicking sounds during sharp turns may suggest problems with the outer joint. Symptoms of constant velocity axle failure can include clicking noises, grease leakage, and driving vibrations, highlighting the need for accurate diagnosis and potential replacement of the entire axle assembly. Additionally, intermittent vibrations felt in the steering wheel at higher speeds may be linked to CV joint issues, which can be mistaken for out-of-balance wheel vibrations. CV joint failure often results from decreased lubrication, leading to increased metal-on-metal contact and diminished shock absorption, ultimately causing vibrations in the steering wheel. It is advisable for owners experiencing these issues to have their axle assembly inspected by a qualified mechanic for proper diagnosis and resolution.