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Q: rear end knocking noise on 2001 Ford F-350 Super Duty

when first stepping on the gas, I hear a knocking noise in the rear end. Don't hear it again, unless I start from stop position. Anyone know what that might be?
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check to see if your spare tire is tightened down. My spare did the same thing and dented my exhaust and I didn't even realize it until the cable broke and I lost the spare.
It could be your drive shaft or your rear end. I would get this resolved because something will break at some point.
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