I'm getting misfire codes on #1 and #2 cyl. What do I need to do to fix it

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I get P0300 P0301 P0302 codes. I have changed all 8 plugs and the coils for cyls 1 & 2 and still get the same codes. And the engine is still running rough. What could be next? Is there something in common with cyl 1 & 2 that can be changed? Thanks.