What could be causing my engine to misfire?

Hi, this is Bo, an auto expert on RepairPal's Car Genius team! If you've already replaced the coil packs and spark plugs on cylinder 1 and are still getting a misfire, we might be dealing with something deeper. Since the issue shows up in 5th gear at higher RPMs, it could be a fuel delivery problem, like a clogged injector or fuel filter. Another possibility is a compression issue (yikes)—if cylinder 1 isn't getting proper compression, it won't fire correctly, no matter how fresh the spark plugs are. Lastly, a faulty wiring connection to the injector or coil pack could be playing tricks on you. This would be the first thing to check before throwing parts at it! Good luck! If you need any further advice or if you'd like any help finding a trusted RepairPal shop in your area, please feel free to call us at 877-913-1554!