It could be a loose fuel filter housing or leaking fuel filter housing o-ring etc. Not uncommon. How old or new is the fuel filer, was it recently replaced?
here are some shops:
https://repairpal.com/ford-repair-in-rock-hill-south-carolina
RepairPal Certified shops can diagnose and repair your 2000 Ford F-250 Super Duty. They provide transparent pricing with a minimum 12-month or 12,000-mile warranty on repairs and services.
The fuel filter was recently replaced