truck falls on its face

What is your question?

I travel alot from TN to OH. On one of my trips, my truck sounded like it was only firing on a couple cylenders. Come to find out, the fuel pump went out. I replaced the fuel pump. The problem fixed for a short period of time. Now home in TN I can't drive it a mile down the road engine warm or cold truck still falls on its face , poping and cracking under the hood just like I am running on 3 or 4 cylenders and that's it. Plugs, wires, distributer cap and rotor button have all been changed. Will a fuel system vacuum cause this problem if the canisters went out??? (Even if you don't hear an air leak.)