Ford F-150 rough idle and misfire on piston 6 with upstream O2 sensors reading rich, unresolved after replacing O2 sensors, coil packs, and spark plugs on Ford F-150

Some Ford F-150 owners report experiencing a rough idle and misfire specifically on piston 6, even after replacing O2 sensors, coil packs, and spark plugs. These issues may stem from a faulty ignition coil, which can cause stumbles at low RPM and misfires. Additionally, a clogged or dirty air filter can restrict airflow into the engine, contributing to rough idle conditions. Furthermore, while new O2 sensors are often installed as part of troubleshooting, problems with other sensors or their wiring may still exist. Owners are advised to check the functionality of the ignition coil, inspect the air filter for clogs, and verify that the new O2 sensors are operating correctly. If these issues persist, seeking professional assistance from a mechanic or dealership experienced in Ford F-150 diagnostics is recommended to effectively resolve the problem.