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Estimates last updated June 18, 2026

2021 Mercedes-Benz E350 Drive Axle Assembly Drain & Refill Cost

The average cost for a 2021 Mercedes-Benz E350 Drive Axle Assembly Drain & Refill is between $120 and $149.

Labor costs are estimated between $61 and $90 while parts are typically priced around $59.
This range does not include taxes and fees, and does not factor in your unique location. Related repairs may also be needed.
For a more accurate estimate based on your location, use our Fair Price Estimator below.

Drive Axle Assembly Drain & Refill

What is a differential?

The purpose of the differential is to distribute engine energy to the axles so the axles spin the wheels the right way at the right speed. The differential also allows the front wheels to spin at different rates as a vehicle rounds a corner. The inside wheel spins slower than the outside wheel when turning; this "difference" is how the differential gets its name.

How does a differential work?

As the transmission turns the drive shaft, the drive shaft turns the pinion gear inside the differential. When the pinion gear is turned, it drives the ring gear. That gear combination transfers rotational force from the drive shaft to the drive axles.

What are the symptoms related to a differential fluid problem?

Differentials tend to make excessive noise when they are low on gear oil. The clattering of gears while driving will be a sure sign there is a problem. Also, the traction control light may illuminate in some vehicles, and there may be a loud slapping noise when “D” or “R” is selected.

Mercedes-Benz Drive Axle Assembly Drain & Refill Cost Estimates

The average cost for a Drive Axle Assembly Drain & Refill is between $120 and $149 but can vary from car to car.

Mercedes-Benz E350 Drive Axle Assembly Drain & Refill Cost by Year

The average cost for a Mercedes-Benz E350 Drive Axle Assembly Drain & Refill is between $120 and $149 but can vary from car to car.

2025 Mercedes-Benz E350

$134-$174

2024 Mercedes-Benz E350

$134-$174

2022 Mercedes-Benz E350

$120-$149

2021 Mercedes-Benz E350

$120-$149

2020 Mercedes-Benz E350

$120-$149

2016 Mercedes-Benz E350

$120-$149

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Drive Axle Assembly Drain & Refill

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What is a differential?

How does a differential work?

What are the symptoms related to a differential fluid problem?

Can I drive with a differential fluid problem?

Never drive a vehicle that is very low on gear oil in the differential. There is a strong possibility of damage to the differential, drive shaft, U-joints, and drive axles. If there is only a small leak, and it is caught early, driving the vehicle should not cause any issues. Get this fixed by a RepairPal Certified Shop

How often does the differential fluid need to be replaced?

The front differential contains gears and bearings that are lubricated by oil. Like all oils and fluids in a vehicle, the oil in the differential should be changed at the vehicle manufacturer specified interval or more frequently if you use your vehicle to tow or carry heavy loads, or there is a leak in the differential.

How are differential fluid issues diagnosed?

If the gears in the differential are making noise while driving, or a slapping noise when going into gear, but no leak is present, the fluid may need to be changed due to age, or incorrect type.

How is differential fluid replaced?

Replacing gear oil is quick and straightforward. The gear oil is drained from the lower drain plug, or by removal of the differential cover. The differential cover, if not already, is removed, and the differential housing will be cleaned and inspected. If no further repairs are needed, the differential cover is installed, and the differential will be filled with the appropriate type and grade of gear oil.

What is a differential?

The differential is an important driveline component responsible for connecting the drive shaft to the drive axles. It is also responsible for mechanical traction control in some models.

RepairPal Recommendations for differential fluid changes

There are many brands and types of gear oil available to consumers. Many manufacturers supply a proprietary type that is designed to meet the specifications of that vehicle. They may also indicate optional recommended brands. These recommendations should be followed to help ensure the longevity of the differential.

What to look out for when dealing with differential fluid changes

If vehicles are used in a method consistent with severe duty, as described by the owner’s manual, the severe duty service schedule should be followed. This will include a shorter interval for changing differential oil. Some FWD and AWD vehicles have front differentials that share the differential fluid with the transmission fluid and these two services are essentially one service.

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