Nissan TITAN engine won't stay running after running out of gas, showing code P0301 despite ignition coil replacement on Nissan TITAN

Some Nissan TITAN owners report experiencing engine stalling issues after running out of gas, accompanied by trouble code P0301, despite having replaced the ignition coil. They note that running out of gas can introduce air into the fuel system, leading to problems with fuel delivery and combustion. The P0301 code indicates a misfire in cylinder 1, which may stem from faulty spark plugs, fuel injector issues, vacuum leaks, or low compression in that cylinder. Even after replacing the ignition coil, some owners find that other components like spark plugs, fuel injectors, or the fuel filter could still be contributing to the misfire. Additionally, they emphasize the importance of ensuring the fuel system is free from clogs or contaminants, checking for vacuum leaks, and verifying the functionality of the fuel injectors as crucial steps in diagnosing and resolving the engine issues. A thorough inspection of the fuel and ignition systems, along with engine components related to cylinder 1, is recommended to effectively address the problem.