Mercedes-Benz S350 key fob malfunction preventing vehicle locking and starting on Mercedes-Benz S350

Submitted by Vehicle Owner · Jun 23, 2025
Published by RepairPal

Problem overview

Some Mercedes-Benz S350 owners report experiencing issues with their key fob that prevent the vehicle from locking and starting. Commonly, this malfunction is attributed to a dead coin battery within the key fob, which is the most frequent cause of keyless entry failures. Additionally, owners may encounter problems due to worn buttons, poor battery contact, water damage, or issues with the receiver module. Signal interference and a dead 12-volt battery in the vehicle can also contribute to these issues. Some owners find that a blown fuse in the central locking system or the need to reprogram an unpaired key fob can hinder functionality. Even after replacing the key fob battery, intermittent behavior may occur if the car battery is low or dead, as it affects the key fob's ability to transmit signals. To resolve these issues, it is advisable for owners to check the key fob battery, inspect for wear or damage, verify the vehicle's battery status, and troubleshoot any signal interference problems.

1 person reported this problem
0 comments
Schedule Repair

Mercedes-Benz S350 vehicles with this problem

0 model year affected

Search for another problem

RepairPal Car Genius

Ask our experts about your Mercedes-Benz.

RepairPal Car Genius™ is a free resource for vehicle owners seeking advice on maintenance, auto repair, shop inquiries, estimates, and finding a trustworthy repair shop in your area.

 Auto Repair Expert Auto Repair Expert

Call us at 877-913-1554

Available 9am – 6pm ET Monday through Friday

Call Our Experts