Some Mercedes-Benz E350 owners report experiencing issues with the anti-theft protection, which can prevent the ignition from turning on. This problem may arise if the COMAND unit needs resetting to disable the anti-theft feature. Additionally, if the Electronic Ignition Switch (EIS) is damaged, it may require replacement by a qualified mechanic or an authorized dealer. In some cases, owners find that reprogramming the EIS and keys is necessary to resolve the ignition issue. Furthermore, the immobilizer system may block the ignition if an incorrect key is used, preventing the engine from starting. If these steps do not resolve the issue, it is recommended to seek assistance from an authorized Mercedes-Benz center.
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