Chevrolet S10 engine roughness and flashing check engine light due to misfire code P0300 and low compression on Chevrolet S10

Submitted by mwood · Jun 23, 2025
Published by RepairPal

Problem overview

Some Chevrolet S10 owners report experiencing engine roughness and a flashing check engine light, often associated with diagnostic trouble code P0300, which indicates random or multiple cylinder misfires and low compression. These symptoms can stem from issues such as incomplete combustion due to engine misfires, which may lead to rough idling and shaking. Common causes identified include problems with the ignition system and low compression levels in the cylinders, both of which can severely impact engine performance. Owners are advised to seek immediate attention, as a flashing check engine light signals a serious engine problem that could lead to further damage if driven in this condition. Given the complexity of these issues, a professional inspection is recommended to accurately diagnose and address the underlying causes of the misfire and low compression. Prompt resolution is crucial to prevent damage to critical components and to maintain the vehicle's performance and longevity.

11 people reported this problem
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Chevrolet S10 vehicles with this problem

Average mileage: 158,400 miles
(128,000 - 205,000)

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