Some Mercedes-Benz S63 AMG owners report experiencing engine failures related to design and material issues, particularly with the 2006-2010 W221 S63 AMG M156 engine, which is known for premature camshaft wear that produces a ticking sound when the engine is cold. Additionally, owners have noted that the V8 engines can overheat under stress, leading to the deterioration of nearby fuel hoses and components, with the crankcase breather valve being especially prone to failure. While the M157 engine is generally considered reliable, some owners report encountering common problems that can be mitigated through regular maintenance and care. These issues highlight the importance of understanding the vulnerabilities of specific engine models and the necessity of routine maintenance to prevent or address potential failures.
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