Models with electric sliding doors can develop problems with the door mechanism. The cable in the door becomes frayed, which will damage the electric motor.
Problems for specific Toyota Sienna years:
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Most reported 2001 Toyota Sienna problems
Sludge can build up in the engine because Toyota did not recommend frequent enough oil changes. Lexus will sometimes offer a discount on cleaning the engine if necessary. Owners who changed their oil every 3,000 miles did not experience these problems. This sludge build up can lead to excessive oil consumption.
ABS light on, Speedo doesn't work, trans has erratic shifts