The door for the vanity mirror (or the frame for the door) can break; due to a redesign, the mirror "cassette" will need replacement.
Car problem reports
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Most reported 2006 Mercedes-Benz S500 4MATIC problems
The relay which turns the airmatic suspension pump on may fail causing the pump to run continuously. This can result in failure of the pump motor or a dead battery as the pump motor will continue to run after the car is turned off. Also, Worn airmatic pump mount bushings can causes noises in the front axle while driving on bumpy roads or a buzzing noise while the pump is running.
A door control module/actuator may fail. Our technicians recommend finding an expert to repair them. Taking the door trim panels off requires expert knowledge because they can break and the pieces are very expensive.
The center console armrest can break. Replacement is commonly the recommended repair.
The engine may develop a stalling and/or no start condition due to a failed crankshaft position sensor.
An engine oil leak may develop from the oil level sensor. Replacement of the leaking sensor will commonly correct this concern.
An engine Oil leak may develop from the PCV vent housing on the valve cover and/or the inspection plate on the front of the engine.
The active body control system can leak fluid from numerous areas, including the tandem pump, hydraulic lines, struts, and/or seals. If it is not repaired, the vehicle ride height could drop too low and cause damage to the undercarriage.
The rubber bond in the harmonic balancer can decay, which causes the balancer to move and work its way toward the timing cover. If the balancer comes into contact with the timing cover while the engine is running, it will fracture and damage the cover and potentially other surrounding parts. The harmonic balancer should be inspected at every service.
The ESP and BAS warning lights may illuminate due to a failed brake light switch. Replacement of the failed switch should correct this concern.