The door for the vanity mirror (or the frame for the door) can break; due to a redesign, the mirror "cassette" will need replacement.
Resources for the Repair and Maintenance of your 2006 Mercedes-Benz S500
2006 Mercedes-Benz S500
2006 Mercedes-Benz S500 Problems
CD changers, command units, voice control units, PSE units, and Tele Aid units are prone to failure, especially in early models.
The brakes may begin to squeak at about the 50 percent wear point. This is due to the size and material used for the brake pads and rotors. The brake rotor surfaces become uneven, causing a lip to form at the outer edge. This will generally require replacement of the rotors when the pads are worn (pad life varies depending on driving style and terrain).
The crankshaft position sensor may fail. Symptoms of this are: The engine will crank—but not start—especially when the engine is warm. The car may start again if it is left to cool off, but it may run roughly or have poor performance.
Leaks may develop from the differential cover and/or seals on high mileage or older vehicles. Our technicians recommend a complete reseal of the differential unit if these leaks are addressed.
2006 Mercedes-Benz S500 Questions and Answers
Regular oil & Filter change
Have imported it from another country and the comand controls the clock by GPS. So would like to adjust the clock to my time zone. I can't use the Navi.