A problem with the ball joints can cause a creaking noise. There is an updated part to remedy this problem.
2010 Mercedes-Benz R350 Problem Reports
Most Reported 2010 Mercedes-Benz R350 Problem Reports
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As a way to increase braking performance, the brake pads and rotors are make of a softer material and may be in need of replacement after approximately 20,000 miles; owners should be vigilant about getting their brakes checked.