Due to the size and material used on the brakes of these vehicles, the brakes may start to squeak around the 50 percent wear point. The brake rotor surfaces become uneven, causing a lip to form at the outer edge of the rotor. Because of this, the rotors are usually replaced when the pads are worn (pad life varies depending on driving style and terrain).
Car problem reports
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Most reported 2011 Mercedes-Benz E550 problems
Vehicles equipped with a 7-speed automatic transmission may develop a rough shifting condition, most commonly going up from first to second gear and going down from third to second or second to first gear. Our technicians tell us this is due to an internal component failure. Mercedes has released updated parts; the transmission will need to be removed and disassembled to complete the necessary repairs.