Problems for specific Mercedes-Benz CL600 years:
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Most reported 2005 Mercedes-Benz CL600 problems
The door for the vanity mirror (or the frame for the door) can break; due to a redesign, the mirror "cassette" will need replacement.
Analog Tele Aid units are no longer supported and must be updated to digital, preferably at a dealership or a well-equipped independent shop. The update and all related factors should be completed at the same time.
CD changers, command units, voice control units, PSE units, and Tele Aid units are prone to failure, especially in early models.