Models with electric sliding doors can develop problems with the door mechanism. The cable in the door becomes frayed, which will damage the electric motor.
Problems for specific Toyota Sienna years:
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Most reported 2005 Toyota Sienna problems
Multiple cracks may develop on the upper surface of the dashboard. At this time, the only suggested repair is to replace the dashboard.
We bought our 2004 Sienna new, drove it in town and on vacations. The transmission died at 250000 mms or about 155000 miles. It would have cost more to replace the transmission than the value of the car so it had no trade-in value. Toyota's usual reliability and resale value was sorely missing.