Overheating and/or lack of proper venting can cause the rear axle seals to leak. Excessive fluid loss can result in major damage to the rear differential assembly and/or axle bearings.
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Most reported 2010 Nissan Titan problems
Water can cause corrosion in the connector between the engine and transmission wiring harness. The engine may crank but not start, stall, and/or the transmission may not shift correctly.