The door for the vanity mirror (or the frame for the door) can break; due to a redesign, the mirror "cassette" will need replacement.
Problems for specific Mercedes-Benz S500 years:
Car problem reports
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Most reported 2001 Mercedes-Benz S500 problems
CD changers, command units, voice control units, PSE units, and Tele Aid units are prone to failure, especially in early models.
The brakes may begin to squeak at about the 50 percent wear point. This is due to the size and material used for the brake pads and rotors. The brake rotor surfaces become uneven, causing a lip to form at the outer edge. This will generally require replacement of the rotors when the pads are worn (pad life varies depending on driving style and terrain).
Problems with the pneumatic system can cause closing assist and door lock issues.
The crankshaft position sensor may fail. Symptoms of this are: The engine will crank—but not start—especially when the engine is warm. The car may start again if it is left to cool off, but it may run roughly or have poor performance.
Leaks may develop from the differential cover and/or seals on high mileage or older vehicles. Our technicians recommend a complete reseal of the differential unit if these leaks are addressed.
The relay which turns the airmatic suspension pump on may fail causing the pump to run continuously. This can result in failure of the pump motor or a dead battery as the pump motor will continue to run after the car is turned off. Also, Worn airmatic pump mount bushings can causes noises in the front axle while driving on bumpy roads or a buzzing noise while the pump is running.
The center console armrest can break. Replacement is commonly the recommended repair.
The active body control system can leak fluid from numerous areas, including the tandem pump, hydraulic lines, struts, and/or seals. If it is not repaired, the vehicle ride height could drop too low and cause damage to the undercarriage.
An engine Oil leak may develop from the PCV vent housing on the valve cover and/or the inspection plate on the front of the engine.