There are known convertible top issues.
Car problem reports
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Most reported 2007 Honda S2000 problems
A problem can occur with a vibrating expansion valve in the AC system which causes a whistling noise from the passengers vent. Replacing the expansion valve with an updated valve from Honda should repair this problem.
On certain models the PCM misinterprets data from the coolant sensor and causes the Check Engine light (MIL) to illuminate. A software update from Honda will repair this problem.