The high pressure diesel fuel injection pump may fail, resulting in a "no start" condition.
Problems for specific Ford F-350 Super Duty years:
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Most reported 2010 Ford F-350 Super Duty problems
Software enhancements are available to remedy inconsistency and confusion about the Diesel Particulate Filter (DPF) cleaning cycle - “Regeneration” mode. The Powertrain Control Module (PCM) will need to be reprogrammed to add several enhancements, including a more reasonable driving experience during the cleaning cycle and instrument cluster notifications of the cleaning status.
The cooler for the EGR valve can leak coolant internally, which causes white smoke to come from the tail pipe. Hot exhaust gases are cooled by the EGR cooler before being circled back into the engine.
If the driveline angle is out of adjustment, it can cause shuddering from the vehicle when accelerating from a stop. The driveline angle should be adjusted to reduce vibration in most driving conditions.
If the engine cranks but will not start, this may be caused by damaged wiring to the high pressure fuel pump. Wiring to the pump can be chafed, which causes the pump to stop working. The chafed wires will need to be accessed and repaired.
noticed at about 87,000 miles that I had some oil spots under the truck when parked. Turns out the dipstick tube rotted out and needed to be replaced. It's all over the internet, but Ford won't issue a recall on it. Paid the dealer about $350 to replace. UGH!