The cooler for the EGR valve can leak coolant internally, which causes white smoke to come from the tail pipe. Hot exhaust gases are cooled by the EGR cooler before being circled back into the engine.
Problems for specific Ford F-250 Super Duty years:
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Most reported 2011 Ford F-250 Super Duty problems
The high pressure diesel fuel injection pump may fail, resulting in a "no start" condition.